serrapeptase systemic enzymes

serrapeptase enzymes

Metabolic Systemic Enzymes - Serrapeptase
Metabolic Systemic Enzymes / Serrapeptase

Brand                    World’s Strongest Serrapeptase            Acid Armor®**                 Considered Enteric Coating?                        SPU                    Price per bottle
                                                                                                     (extra-thick                                                                
                                                                                                     cellulose layer)                                                                                   Per two Capsules          
                                                                                                                                                                                                                                                               
Serrétia                                No                                                               Yes                                              No                                                  250,000                      $55.99 for
(Arthur A                                                                                                                                                                                                                                                  90 capsules


Serrapeptase                     Yes                                                               —                                               Yes                                                  260,000                     $59.98 for
(AST Enzymes)
                                                                                                                                                                                                                                     120 capsules
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Enzyme Research                    Serracor vs. Neprinol             Excellacor vs. Vitalzym
Systemic Enzymes
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Systemic Enzymes
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Compare
Peptizyme-SP vs. Serrétia**
Enteric Coating Comparison
                                                                      Methacrylic Acid                         Cellulose Acetate                         Hydroxypropyl Methylcellulose                        Acid Armor®
                                                                      Copolymer                                      Phthalate (CAP)                                 Phthalate (HPMCP)
              
                                                                      (MAAC)*                                                                                                                                                                     (extra-thick cellulose layer)**


Contains Phthalates                                       NO                                                        YES                                                           YES                                                        NO


Considered Enteric Coating                          YES                                                       YES                                                            YES                                                        NO


Studies supporting Efficacy as                    YES                                                        YES                                                           YES                                                        NO
       Enteric Coating


Gastro-resistance                                           YES                            
                            YES                                                            YES                                                  UNKNOWN


FDA GRAS                                                          YES                                                        YES                                                            YES                                                       YES


Time in Use                                                 >50 years                                                >70 years                                                ~40 years                                                ~1 year





*AST Enzymes uses MAAC as enteric coating

What is enteric coating, and why is it needed?

Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the
small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric
coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects.

What’s enteric coating made of?

At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent
studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and
Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in
the small intestine and absorbed successfully.

MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, the
European Food Safety Authority – an organization that conducted studies which led to the ban of six types of phthalates in personal care products in Europe in 2004 –
has deemed MAAC safe for use as coating agent in food supplements.

Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted
various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment.

Serrapeptase Units: Facts OR Fiction?!

The strength of enzymes is measured by activity (SPU), not quantity (mg).

The enzyme unit (U) is a unit for the amount of a particular enzyme. One U is defined as the amount of the enzyme that produces a certain amount of enzymatic activity,
that is, the amount that catalyzes the conversion of 1 micro mole of substrate per minute.2

Enzyme activity is equal to the moles of substrate converted per unit of time under standard conditions. An increased amount of substrate will increase the rate of
reaction with enzymes; however, once the reaction exceeds a certain point Vmax, the rate of reaction will become linear because the amount of active sites will remain
constant.

Figure 1: the above figure illustrates a Michaellis Menten Plot. This shows that an  increase in substrate will increase the reaction rate until a certain point is reached
(Vmax) then it will level off constant as all of the active sites have remained constant.

Now that we understand how enzymes work on a biochemical level, how do we measure the units of activity specifically for Serrapeptase, and what do they mean?

If you have been researching the wide variety of options for Serrapeptase on the market today you have surely come across an extensive list of units that seem to leave
people confused.

A shortlist includes: mg, IU, SU and SPU.

Milligrams (mg): an accurate unit of measurement for weight. However, the weight of an enzyme can contain low activity levels or high activity levels.

A high quality enzyme has low weight and high activity, ensuring purity. The activity level of the enzyme is what is vital to its effectiveness.

International Unit (IU): a unit of measurement for the amount of substance; mass or volume that constitutes one international unit caries based on the substance being
measured. IU is used to quantify vitamins, hormones, some medications, vaccines, and blood products. “The enzyme unit should not be confused with the international
Unit (IU), and unrelated measure of biologically active substances.”6 Despite its name, IU is not part of the International System of Units physics and chemistry. “The IU
should not be confused with the enzyme unit, also known as the International unit of enzyme activity and abbreviated as U.4” Companies that continue to use this unit
(IU) to describe the activity of Serrapeptase are incorrect.

Serrapeptase Unit (SU) or (SPU): both are used interchangeably, and are accepted and accurate in industry. However, SU may create some confusion. SU is a unit
used in the digestion of Invertase (Sucrase). One SU (Sumner Unit Invertase/Sucrase) is the FCC assay of measurement, whereby one Sumner Unit is the quantity of
enzyme that will convert 1 mg of sucrose to glucose and fructose in 5 minutes.

As you can see this can become problematic using the same units for different processes already defined.7 While both SU and SPU are used today in industry, the most
accurate unit to describe the activity of Serrapeptase is (SPU).

As a final point in summary, the potency of the enzyme is the most crucial factor in determining how well it will work, and this is measured by activity not by weight. The
most accurate unit of measure for Serrapeptase is (SPU), Serrapeptase Units.

Serrapeptase

Don’t be misled by deceiving marketing strategies by other companies claiming to have serrapeptase with 250,000 SPU. They claim they have the strongest
Serrapeptase because their product contains 250,000 SPU of serrapeptase per “dosage”—which in most cases is 2 capsules. Therefore, each capsule only has
125,000 SPU.

AST Enzymes is the largest manufacturer of Serrapeptase in the world and happens to carry the strongest Serrapeptase on the market with 130,000 SPU per capsule!
Our quality and prices of our products speak for themselves.

Our serrapeptase is enteric coated to survive the acidic conditions of the stomach without being degraded. This allows for optimum absorption in the small intestine and
greater systemic activity. The pH resistant enteric coating disintegrates after it enters the alkaline environment of the intestine.

Most serrapeptase brands on the market are not enteric coated, which means this low-pH sensitive enzyme can lose activity, and thus effectiveness, when entering the
stomach. The enteric coating in Serrapeptase allows the enzymes to survive the acidic conditions of the stomach, which increases absorption in the small intestine,
systemic activity and efficacy.

References:

1)      Nomenclature Committee of the International Union of Biochemistry (NC-IUB) (1979). “Units of Enzyme Activity”. Eur. J. Biochem. 97 (2): 319–20. doi:10.1111/j.1432-
1033.1979.tb13116.x.

2)   Principles of Biochemistry, page 94, 4th Edition, Lehninger.

3)   https://en.wikipedia.org/wiki/Enzyme_unit

4)   https://en.wikipedia.org/wiki/International_unit

5)   Canadian Society of Clinical Chemists (Dec 1992). “Canadian Society of Clinical Chemists position paper: standardization of selected polypeptide hormone
measurements.”. Clin Biochem. 25 (6): 415–24. doi:10.1016/0009-9120(92)90030-V. PMID 1477965.

6)   Facts about the Official “Do Not Use” List”(PDF). The Joint Commission. Archived from the original(PDF)on March 10, 2013. Retrieved 30 May2013.

7) http://www.globalhealingcenter.com/natural-health/invertase/

** Serrétia™ and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other
product from Specialty Enzymes & Biotechnologies or AST Enzymes.