Methacrylic Acid        Cellulose Acetate             Hydroxypropyl                                         Acid Armor®
                                Copolymer                 Phthalate (CAP)              Methylcellulose Phthalate             (extra-thick cellulose layer)**
                                (MAAC)*                                                            (HPMCP)

Contains Phthalates                    NO                             YES                                    YES                                                       NO

Considered Enteric                     YES                            YES                                    YES                                                       NO

Studies supporting                      YES                            YES                                    YES                                                       NO
Efficacy as Enteric

Gastro-resistance                        YES                           YES                                     YES                                                UNKNOWN

FDA GRAS                                  YES                            YES                                     YES                                                      YES

Time in Use                                >50 years                >70 years                         ~40 years                                                 ~1 year

*AST Enzymes uses MAAC as enteric coating

What is enteric coating, and why is it needed?

Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach
and be absorbed in the small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions
of extreme pH and temperature. Without enteric coating, enzymes would be rendered useless long before they reach the bloodstream, where
their carry out their beneficial effects.

What’s enteric coating made of?

At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate.
According to independent studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as
Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand
the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully.

Don’t let the name scare you. MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50
years with no reported side effects. In fact, the
European Food Safety Authority – an organization that conducted studies which led to the ban
of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements.

Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection
Agency (EPA) also conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will
not adversely affect public health or the environment.

** Neprinol® and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this
product or any other product from Specialty Enzymes & Biotechnologies or AST Enzymes.

serracor-nk systemic enzymes

serracor-nk enzymes

Metabolic Systemic Enzymes - Serracor NK
Metabolic Systemic Enzymes / Serracor-NK

Brand              Enteric coated Serrapeptase               Enzyme Stabilizer BPPS®               Enzyme Manufacturing          Price
                         and Nattokinase                                                                                                     

Neprinol                                 Yes                                                        Yes                                                     India                         $144.99

Neprinol                                  No                                                      Unknown                                               Japan *                      $144.99

Serracor-NK                           Yes                                                        Yes                                                     India                         $124.99


AST Enzymes recently learned of false claims, misstatements and misrepresentations by one of our competitors. These claims call into question
the business practices of Specialty Enzymes and Biotechnologies and the quality of Serracor-NK.

Specialty Enzymes & Biotechnologies (SEB) is a major international manufacturer of enzymes for more than 20 industries, including the
nutraceutical industry. Vic Rathi, president and founder of SEB, formulated the original Neprinol® for Arthur Andrew Medical (AAM), an enzyme
marketing company. The proprietary formula remains the intellectual property of SEB; AAM was not privy to the formula.

SEBkinase® is a blend of enteric-coated nattokinase and serrapeptase, which was first introduced in commerce by SEB in 2002. Two years
later, in 2004, SEB was contracted to formulate and make finished products, not raw material, for AAM and SEBkinase became an integral part
of the original formula of Neprinol until 2008. During the duration of this contract:

  •    SEB received no complaints, verbal or in writing, at any point about the quality and efficacy of Neprinol.
  •    SEB did not provide any Neprinol product to AAM in 2009, so any complaints or refunds made thereafter were not for its products. A  
    major distributor who worked with AAM at the time says they did not receive any complaints nor requests for refunds, and there was no
    apology issued to customers.
  •    A review of the batches of Neprinol sold during that time shows activity levels were in accordance with AAM’s requests. In addition, the
    weight of the powder inside the capsules was within the accepted range of label claims and GMP Standards.
  •    Initial production and sale of Serracor-NK was the result of feedback from previous Neprinol customers who contacted SEB as the
    manufacturer, requesting the original SEBkinase formula.

The quality of SEB products and services are evident in the fact that it has been in business for more than 50 years and continues to
experience tremendous growth. In fact, in 2010 SEB expanded its manufacturing facilities, adding a new 25,000 square foot building to meet
growing manufacturing demands. Thousands of satisfied customers can attest to the quality and efficacy of our products, and the integrity of
our business practices.

Specialty Enzymes & Probiotics is an innovator, creating and manufacturing several of the best-selling enzyme supplements on the market today.

Please feel free to call us with questions.

Serracor-NK SEBkinase Formula Remains Unchanged

Specialty Enzymes did not change the formula for SEBkinase or the original formula for Neprinol, which is now available from AST Enzymes as
Serracor-NK. Claims that we allegedly lowered the activity of SEBkinase in the original Neprinol formula are untrue. Our SEBkinase blend is
unchanged since its introduction. The SEBkinase in Serracor-NK is the same as the SEBkinase in the original formulation of Neprinol. Nothing
has changed but the name.

Enteric Coated Serrapeptase and Nattokinase

All enzymes have a pH range.  At the extremes of this range, whether acid or alkaline, systemic enzymes will denature (become irreversibly
inactive). While it is true that most fungal and plant source systemic enzymes exhibit a fairly broad pH range, some bacterial sourced systemic
enzymes are less tolerant of low pH. Because we are the actual manufacturer of our enzymes, we test them for both pH and temperature
stability.  Based on the results of these kinetic studies, we have repeatedly demonstrated that serrapeptase and nattokinase are much less
tolerant of a low pH and will begin to lose activity in acidic conditions consistent with the stomach.  Therefore, for maximum effectiveness,
serrapeptase and nattokinase are best when enterically coated.

When we design a systemic enzyme blend for human consumption, we have to ensure that it will tolerate the pH variables of our gastrointestinal
system. We have successfully done this with our systemic enzyme products, including Peptizyme SP (enteric coated serrapeptase), NattoSEB
(enteric coated nattokinase) and SEBKinase (a blend of Peptizyme and NattoSEB).  As a result of our experience and expertise, our entire line
of enteric-coated enzymes are able to reach the small intestine with higher activity for full systemic enzyme therapy.

Make an Informed Choice

There are several systemic enzyme products on the market today. In this case, there are two alternatives: an enzyme product from an expert
manufacturer or one from a marketing company. You deserve the highest quality and most effective enzyme products available. We encourage
you to make an informed choice.
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Serracor NK vs Neprinol**
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