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Metabolic Systemic Enzymes


A concentrated natural proteolytic enzyme supplement. Our serrapeptase is enterically-coated to maximize efficacy, allowing the enzymes to survive the acidic conditions of the stomach, leading to greater absorption.*

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Enteric-Coated Serrapeptase



Serrapeptase supports healthy respiratory and sinus function, as well as muscle joint and overall tissue health.*

Product Information

Serrapeptase: Enteric-Coated Serrapeptase

Serrapeptase (Peptizyme-SP) for Healthy Fibrin Metabolism

A concentrated natural proteolytic enzyme supplement. Our serrapeptase is enterically-coated to maximize efficacy, allowing the enzymes to survive the acidic conditions of the stomach, leading to greater absorption.*

Why Take AST Enzymes’ Serrapeptase

Serrapeptase supports healthy respiratory and sinus function, as well as muscle joint and overall tissue health.*

The powerful systemic enzyme supplement supports:

  • Healthy Respiratory System*
  • Sinus Health*
  • Muscle, Joint and Tissue Health*
  • Healthy Oxygen Levels*
  • Muscle Recovery*

What’s Inside Serrapeptase

Enteric-coated Serrapeptase

What Isn’t Inside Serrapeptase

Serrapeptase is free of pesticides, chemicals, preservatives, animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts. All individual enzymes are kosher-certified ingredients, and suitable for vegetarians.

All products by AST Enzymes are manufactured in the USA, that follows GMP guidelines.

What Sets AST Enzymes’ Serrapeptase Apart

AST Enzymes’ Serrapeptase is the strongest in the world, unrivaled among products of its kind because it is packed with 130,000 SPU per capsule (80K is also available).

Serrapeptase – also known as serrapeptidase, serratiopeptidase and serratia peptidase – is a powerful proteolytic enzyme derived from a species of bacteria originally found in the intestine of silkworms. The bacterium, Serratia mercesans, produces the enzyme serrapeptase to enable the silkworm to dissolve its silken cocoon and emerge as a moth after metamorphosis. Serratia is now grown in cultures to produce serrapeptase by fermentation, and is suitable for vegetarians.

How Enteric Coating Makes  AST Enzymes’ Serrapeptase Uniquely Effective

Most serrapeptase brands on the market are not enteric coated, which means they can lose a significant portion of their effectiveness in the acidic environment of the stomach. The enteric coating of our blend maximizes their efficacy by allowing these sensitive enzymes to survive the acidic conditions of the stomach, allowing them to pass into the circulatory system and maintain high activity levels.

Why Choose  AST Enzymes’ Serrapeptase

Our Serrapeptase is the most potent on the market with an enteric coating, and is specially formulated to maximize its effectiveness. ISO 9001: 2000 and GMP certified facilities, and undergo rigorous quality testing.

How to Take Serrapeptase 80,000 SPU

Take on an empty stomach (30-60 minutes before or 2 hours after meals).

Days 1-5: Take 1 capsule, twice a day.
Days 6-12+: Take 2+ capsules, twice a day (if needed).

How to Take Serrapeptase 130,000 SPU

Take on an empty stomach (30-60 minutes before or 2 hours after meals).

Days 1-5: Take 1 capsule, twice a day.
Days 6-12+: Take 2+ capsules, twice a day (if needed).

Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat,cure,or prevent any disease.
SKU: N/A Category: Systemic Enzymes


Peptizyme-SP vs. Serrétia**

BrandWorld’s Strongest SerrapeptaseAcid Armor®**(extra-thick cellulose layer)Considered Enteric Coating?SPU Per two CapsulesPrice per bottle
Serrétia (Arthur A Capsules)NoYesNo250,000$55.99 for 90
SerrapeptaseYesYes260,000$59.98 for 90

Peptizyme-SP vs. Serrétia**

(MAAC)* (extra-thick cellulose layer)**

Contains PhthalatesNoYesYesNo
Considered Enteric CoatingYesYesYesNo
Studies supporting Efficacy as Enteric CoatingYesYesYesNo
Time in Use>50 Years>70 Years~40 Years~1 Years

*AST Enzymes uses MAAC as enteric coating

What is enteric coating, and why is it needed?

Enteric coating is a layer of protective coating for dietary supplements that is meant to allow the supplement to bypass digestion by the stomach and be absorbed in the
small intestine. Systemic enzymes are proteins, so their functional structures are denatured (or destroyed) in conditions of extreme pH and temperature. Without enteric
coating, enzymes would be rendered useless long before they reach the bloodstream, where their carry out their beneficial effects.

What’s enteric coating made of?

At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Methacrylic Acid Copolymer (MAAC) is not a phthalate. According to independent
studies, MAAC is the most gastro-resistant when compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and
Hydroxypropyl Methycellulose Phthalate (HPMCP). This means that MAAC can most effectively withstand the acidity of the stomach, allowing its contents to be released in
the small intestine and absorbed successfully.

MAAC is a food-grade compound that has been in use as enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, the
European Food Safety Authority – an organization that conducted studies which led to the ban of six types of phthalates in personal care products in Europe in 2004 –
has deemed MAAC safe for use as coating agent in food supplements.

Not only is MAAC listed as Generally Recognized As Safe (GRAS) by the Food and Drug Administration (FDA), the Environmental Protection Agency (EPA) also conducted
various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment.

Serrapeptase Units: Facts OR Fiction?!

The strength of enzymes is measured by activity (SPU), not quantity (mg).

The enzyme unit (U) is a unit for the amount of a particular enzyme. One U is defined as the amount of the enzyme that produces a certain amount of enzymatic activity,
that is, the amount that catalyzes the conversion of 1 micro mole of substrate per minute.2

Enzyme activity is equal to the moles of substrate converted per unit of time under standard conditions. An increased amount of substrate will increase the rate of
reaction with enzymes; however, once the reaction exceeds a certain point Vmax, the rate of reaction will become linear because the amount of active sites will remain

Figure 1: the above figure illustrates a Michaellis Menten Plot. This shows that an  increase in substrate will increase the reaction rate until a certain point is reached
(Vmax) then it will level off constant as all of the active sites have remained constant.

Now that we understand how enzymes work on a biochemical level, how do we measure the units of activity specifically for Serrapeptase, and what do they mean?

If you have been researching the wide variety of options for Serrapeptase on the market today you have surely come across an extensive list of units that seem to leave
people confused.

A shortlist includes: mg, IU, SU and SPU.

Milligrams (mg): an accurate unit of measurement for weight. However, the weight of an enzyme can contain low activity levels or high activity levels.

A high quality enzyme has low weight and high activity, ensuring purity. The activity level of the enzyme is what is vital to its effectiveness.

International Unit (IU): a unit of measurement for the amount of substance; mass or volume that constitutes one international unit caries based on the substance being
measured. IU is used to quantify vitamins, hormones, some medications, vaccines, and blood products. “The enzyme unit should not be confused with the international
Unit (IU), and unrelated measure of biologically active substances.”6 Despite its name, IU is not part of the International System of Units physics and chemistry. “The IU
should not be confused with the enzyme unit, also known as the International unit of enzyme activity and abbreviated as U.4” Companies that continue to use this unit
(IU) to describe the activity of Serrapeptase are incorrect.

Serrapeptase Unit (SU) or (SPU): both are used interchangeably, and are accepted and accurate in industry. However, SU may create some confusion. SU is a unit
used in the digestion of Invertase (Sucrase). One SU (Sumner Unit Invertase/Sucrase) is the FCC assay of measurement, whereby one Sumner Unit is the quantity of
enzyme that will convert 1 mg of sucrose to glucose and fructose in 5 minutes.

As you can see this can become problematic using the same units for different processes already defined.7 While both SU and SPU are used today in industry, the most
accurate unit to describe the activity of Serrapeptase is (SPU).

As a final point in summary, the potency of the enzyme is the most crucial factor in determining how well it will work, and this is measured by activity not by weight. The
most accurate unit of measure for Serrapeptase is (SPU), Serrapeptase Units.


Don’t be misled by deceiving marketing strategies by other companies claiming to have serrapeptase with 250,000 SPU. They claim they have the strongest
Serrapeptase because their product contains 250,000 SPU of serrapeptase per “dosage”—which in most cases is 2 capsules. Therefore, each capsule only has
125,000 SPU.

AST Enzymes is the largest manufacturer of Serrapeptase in the world and happens to carry the strongest Serrapeptase on the market with 130,000 SPU per capsule!
Our quality and prices of our products speak for themselves.

Our serrapeptase is enteric coated to survive the acidic conditions of the stomach without being degraded. This allows for optimum absorption in the small intestine and
greater systemic activity. The pH resistant enteric coating disintegrates after it enters the alkaline environment of the intestine.

Most serrapeptase brands on the market are not enteric coated, which means this low-pH sensitive enzyme can lose activity, and thus effectiveness, when entering the
stomach. The enteric coating in Serrapeptase allows the enzymes to survive the acidic conditions of the stomach, which increases absorption in the small intestine,
systemic activity and efficacy.


1)      Nomenclature Committee of the International Union of Biochemistry (NC-IUB) (1979). “Units of Enzyme Activity”. Eur. J. Biochem. 97 (2): 319–20. doi:10.1111/j.1432-

2)   Principles of Biochemistry, page 94, 4th Edition, Lehninger.

3)   https://en.wikipedia.org/wiki/Enzyme_unit

4)   https://en.wikipedia.org/wiki/International_unit

5)   Canadian Society of Clinical Chemists (Dec 1992). “Canadian Society of Clinical Chemists position paper: standardization of selected polypeptide hormone
measurements.”. Clin Biochem. 25 (6): 415–24. doi:10.1016/0009-9120(92)90030-V. PMID 1477965.

6)   Facts about the Official “Do Not Use” List”(PDF). The Joint Commission. Archived from the original(PDF)on March 10, 2013. Retrieved 30 May2013.

7) http://www.globalhealingcenter.com/natural-health/invertase/

** Serrétia™ and Acid Armor® are registered trademarks of Arthur Andrews Medical Inc., which is not affiliated with, nor sponsors or endorses this product or any other
product from Specialty Enzymes & Biotechnologies or AST Enzymes.

Frequently Asked Questions

What is systemic enzyme therapy?

Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce a desired effect. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system.

What is a systemic proteolytic enzyme?

Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Regular systemic proteolytic enzyme use can promote healthy circulation

Why is it important to take Serrapeptase on an empty stomach?

Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serrapeptase with food will compromise their absorption, as well as their effectiveness.

Does Serrapeptase have an enteric coating?

Yes,  the serrapeptase is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. When enzymes are enterically coated, their activity levels are more likely to be preserved until they reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.

Do you use phthalates in your enteric coating?

No, our enteric coating does not use or contain phthalates. At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about enteric coating used in AST Enzymes products, please click the “Compare” tab.

How long should I take Peptizyme-SP before feeling results?

The length of time to experience the benefits of systemic enzymes varies by individual. Some people notice a difference within days. For others, it’s a week or 10 days. For long-term benefits, it’s important to take systemic enzymes consistently over several months.

New systemic enzyme users should start off slow, with one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a 2 capsules, 3 times per day.  monitored, and dosage should be adjusted accordingly. Some consumers find their ideal dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect required dosage, including:





Time of administration (better absorbed on an empty stomach)

Adherence to regimen

Nutritional state

What if I miss a dose?

Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up” on one dose. Also remember, systemic enzymes are best absorbed on an empty stomach.

Does Serrapeptase have any side effects?

The use of Serrapeptase has not been shown to exhibit detrimental effects, long term or short term. Minor side effects may vary. Gastrointestinal disturbances have been reported by a small percentage of new users, but once the dosage is adjusted, tolerance is maintained. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, particularly if you are on blood-thinning medications, or are pregnant or nursing.

Can I take Serrapeptase with other systemic enzymes?

Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Supplements such as Serracor-NK and Serrapeptase often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.

Can I take Serrapeptase with digestive enzymes?

Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.

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